# Metformin Added Nothing to Diet and Exercise for Older Adults' Strength

*Metformin added to lifestyle intervention for physical function in older adults with obesity (DEMFOS trial): a randomised controlled trial.*

- **Evidence Level**: Strong
- **Publication Types**: Journal Article
- **Journal**: The lancet. Healthy longevity
- **Sample Size**: 114 adults aged 65-85 with obesity, mostly men
- **Authors**: Nava MLD, Viola V, Aguilar M, Bryant MS, Nambi V, Armamento-Villareal R, Qualls C, Villareal DT
- **Published**: 2026-07-31
- **Topics**: metformin, exercise, healthy aging
- **DOI**: https://doi.org/10.1016/j.lanhl.2026.100883
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42532077/

## Summary

Metformin hat in der Longevity-Szene viele Fans, doch diese Studie dämpft den Hype. Ältere Erwachsene mit Adipositas zwischen 65 und 85 Jahren absolvierten sechs Monate intensives Ernährungs- und Bewegungsprogramm. Metformin zusätzlich brachte keinerlei extra Verbesserung der körperlichen Funktion gegenüber Placebo. Das Lifestyle-Programm allein war entscheidend.

## Practical Takeaway

This study suggests structured exercise and diet drive physical function gains, not metformin.

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_Canonical: https://longevity-switzerland.com/de/research/metformin-added-nothing-to-diet-and-exercise-for-older-adults-strength · Part of Longevity Cities · Updated 2026-07-31_