# Why Your Skin Never Forgets Inflammation, Even Years Later

- **Evidence Level**: Preliminary
- **Journal**: Science (New York, N.Y.)
- **Sample Size**: Mice (exact number not specified)
- **Published**: 2026-03-26
- **Topics**: epigenetics, inflammation, skin-health
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/41886579/

## Summary

In mice, skin stem cells can hold lifelong "memories" of past inflammation like psoriasis flares. These memories are stored as epigenetic changes. Specific DNA sequences rich in CpG patterns keep the memory accessible through cell divisions. This means once skin has been inflamed, its stem cells stay primed to react faster and stronger to future triggers.

## Practical Takeaway

This study suggests past inflammatory episodes may permanently alter tissue responses to future stressors.

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_Canonical: https://longevity-switzerland.com/de/research/why-your-skin-never-forgets-inflammation-even-years-later · Part of Longevity Cities · Updated 2026-03-26_