# Coenzyme Q10

Coenzyme Q10 (also called ubiquinone) is a fat-soluble molecule. It is essential for mitochondrial electron transport and ATP production, and it acts as an antioxidant inside your cells. Your own levels decline with age, and with statin use. The clinical evidence is strongest in heart failure. In the Q-SYMBIO trial (300 mg a day), CoQ10 cut all-cause death and major cardiovascular events in patients with chronic heart failure. But replication has been inconsistent, and most other trials have been smaller. Effects on blood pressure and statin-related muscle symptoms are modest. And longevity benefits in healthy adults are not established.

## Sources

- Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, et al.. (2014). The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC: Heart Failure. https://doi.org/10.1016/j.jchf.2014.06.008

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_Canonical: https://longevity-switzerland.com/en/glossary/coenzyme-q10 · Part of Longevity Cities · Updated 2026-06-22_