# HOMA-IR

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a fasting blood index of insulin resistance. You calculate it as (fasting insulin in µU/mL × fasting glucose in mmol/L) / 22.5. The equivalent using mg/dL glucose is (fasting insulin × fasting glucose) / 405. It estimates your whole-body insulin resistance from fasting values, mostly reflecting how your liver responds to insulin. It is a low-cost stand-in for the gold-standard clamp test. Cutoffs depend on the population and the assay, with no universal threshold. Values are commonly cited roughly between 1.5 and 2.9 in adults, but there is no agreed number.

## Sources

- Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. (1985). Homeostasis Model Assessment: Insulin Resistance and Beta-Cell Function from Fasting Plasma Glucose and Insulin Concentrations in Man. Diabetologia. https://doi.org/10.1007/BF00280883

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_Canonical: https://longevity-switzerland.com/en/glossary/homa-ir · Part of Longevity Cities · Updated 2026-06-22_