# iAge (immune age clock)

iAge is an 'inflammatory age' score, introduced by Sayed and colleagues (2021, Stanford). It uses a deep-learning model, trained on a panel of 50 blood cytokines and chemokines, from 1,001 healthy people in the decade-long Stanford 1000 Immunomes Project. The model compresses your immune profile into a single inflammatory-age score. That score predicts heart risk, multiple-disease burden, and death from all causes, independent of your calendar age. The single most informative driver was a chemokine called CXCL9, linked to T-cell recruitment and blood-vessel dysfunction. The clock highlights your immune system as a distinct, targetable dimension of aging.

## Sources

- Sayed N, Huang Y, Nguyen K, Krejciova-Rajaniemi Z, Grawe AP, Gao T, Tibshirani R, Hastie T, Heller R, Cheng C, Aghaeepour N, Hadeiba H, Pierre-Jerome E, Snyder MP, Furman D, et al.. (2021). An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging. Nature Aging. https://doi.org/10.1038/s43587-021-00082-y

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_Canonical: https://longevity-switzerland.com/en/glossary/iage · Part of Longevity Cities · Updated 2026-06-22_