# NR (Nicotinamide riboside)

NR is a form of vitamin B3 and another building block for NAD+, the energy-and-repair coenzyme. Your body converts it through salvage pathways (possibly passing through NMN on the way) to raise NAD+. Human trials consistently show that taking NR by mouth lifts NAD+ in your blood and is well tolerated. The open question is whether that translates into real benefits. Evidence for things like better physical performance, metabolic health, or healthspan is mixed, and mostly comes from small, short studies.

## Sources

- Martens CR, Denman BA, Mazzo MR, et al.. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. https://doi.org/10.1038/s41467-018-03421-7

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_Canonical: https://longevity-switzerland.com/en/glossary/nr · Part of Longevity Cities · Updated 2026-06-22_