# Resveratrol

Resveratrol is a stilbene polyphenol, found in grape skins, red wine, and Japanese knotweed. It is studied as a possible sirtuin (SIRT1) activator and AMPK modulator, with effects on inflammation and mitochondrial function in preclinical models. But human trials have given inconsistent results, and it is poorly absorbed when you take it by mouth. As of now, there is no strong evidence that resveratrol supplements extend human lifespan or healthspan.

## Sources

- Howitz KT, Bitterman KJ, Cohen HY, et al.. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. https://doi.org/10.1038/nature01960
- Baur JA, Pearson KJ, Price NL, et al.. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature. https://doi.org/10.1038/nature05354

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_Canonical: https://longevity-switzerland.com/en/glossary/resveratrol · Part of Longevity Cities · Updated 2026-06-22_