# Spermidine

Spermidine is a naturally occurring polyamine, found in wheat germ, aged cheese, soy, and mushrooms, so you already eat some. The content varies a lot by source and processing. It induces autophagy, the cellular recycling process tied to aging. And it extends lifespan in yeast, worms, flies, and mice. In humans, dietary intake correlates with lower death in observational data. A few small early trials have explored possible cognitive signals, but the results are not definitive. So a causal effect on human longevity is not yet established.

## Sources

- Eisenberg T, Knauer H, Schauer A, et al.. (2009). Induction of autophagy by spermidine promotes longevity. Nature Cell Biology. https://doi.org/10.1038/ncb1975
- Kiechl S, Pechlaner R, Willeit P, et al.. (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based study. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqy102

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_Canonical: https://longevity-switzerland.com/en/glossary/spermidine · Part of Longevity Cities · Updated 2026-06-22_