# Therapeutic plasma exchange (TPE)

Therapeutic plasma exchange (TPE) is a specific form of plasmapheresis. In each session, roughly one to one-and-a-half plasma volumes are removed from your blood. That plasma is not re-infused. Instead, it is replaced with albumin, saline, or donor plasma. TPE is standard care for several neurologic and blood (hematologic) diseases. The longevity interest comes from rodent dilution studies that hint at rejuvenation. Small human trials (for example, in Alzheimer's) are early and ongoing. So far, there is no proven anti-aging benefit.

## Sources

- Kim D, Kiprov DD, Luellen C et al.. (2022). Old plasma dilution reduces human biological age: a clinical study. GeroScience. https://doi.org/10.1007/s11357-022-00645-w
- Gulej R, Patai R, Ungvari A et al.. (2026). Plasma-based strategies for systemic rejuvenation: critical perspectives on clinical translation. GeroScience. https://doi.org/10.1007/s11357-026-02136-8

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_Canonical: https://longevity-switzerland.com/en/glossary/therapeutic-plasma-exchange · Part of Longevity Cities · Updated 2026-06-22_