# Caloric Restriction Slows Aging Most in the Heart and Metabolism

- **Evidence Level**: Strong
- **Journal**: Clinical nutrition (Edinburgh, Scotland)
- **Sample Size**: 185 healthy adults (120 CR, 65 control)
- **Published**: 2026-03-14
- **Topics**: caloric restriction, biological aging, cardiovascular
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/41895150/

## Summary

Cutting calories doesn't slow aging evenly across all organs. In a two-year trial, 185 adults were randomly assigned to caloric restriction or normal eating. The caloric restriction group aged about one year less in their cardiovascular and metabolic systems over 24 months. Kidney aging, however, didn't budge, and liver aging only slowed modestly at the two-year mark.

## Practical Takeaway

This study suggests caloric restriction may preferentially protect cardiovascular and metabolic health.

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_Canonical: https://longevity-switzerland.com/en/research/caloric-restriction-slows-aging-most-in-the-heart-and-metabolism · Part of Longevity Cities · Updated 2026-03-14_