# Cholesterol, Immune Cells, and IGF-1 Emerge as Key Longevity Signals

*Genetic and molecular factors underlying human longevity and epigenetic aging.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article
- **Journal**: npj aging
- **Sample Size**: N/A (genetic database analysis)
- **Authors**: Gai K, Li W, Li J, He H, Shi L, Tang M, Wang F, Chang T, Wu Y
- **Published**: 2026-04-16
- **Topics**: longevity genetics, IGF-1, epigenetic aging
- **DOI**: https://doi.org/10.1038/s41514-026-00384-8
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/41991941/

## Summary

Researchers combed through massive genetic databases to find what actually drives long life and slower biological aging. Three factors stood out: cholesterol levels, immune cell traits, and IGF-1 (a growth hormone linked to aging). They also flagged 30 genes and several proteins as possible drug targets for future anti-aging therapies.

## Practical Takeaway

This study suggests cholesterol, immune health, and IGF-1 may be worth monitoring as part of a longevity-focused check-up.

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_Canonical: https://longevity-switzerland.com/en/research/cholesterol-immune-cells-and-igf-1-emerge-as-key-longevity-signals · Part of Longevity Cities · Updated 2026-04-16_