# Clearing Out Aging Cells Made Stem Cell Repair Work Far Better in Mice

*Synergistic senolytic-regenerative therapy significantly extends healthspan and lifespan.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Journal of translational medicine
- **Sample Size**: Mice with induced liver injury and aging (number not specified)
- **Authors**: Ichim TE, Markov N, Lopes G, Pascual KA, Evans A, Reznik R, Bykoriz V, Fortunati CA, Minev B, Ramos RA, Bajnath A, Lin E, Hu J, Marincola FM, Rath A, Barrett B, Jurow A, Sankhala KK, Furman D, Reznik BN
- **Published**: 2026-06-08
- **Topics**: senolytics, stem cells, aging
- **DOI**: https://doi.org/10.1186/s12967-026-08221-y
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42260530/

## Summary

Old, worn-out cells (called senescent cells) seem to block the body's natural repair work. In mice with liver damage and forced aging, combining a treatment that clears these cells with stem cell therapy worked far better than either alone. The combo reversed signs of aging and restored repair signals. This is early animal research, not tested in people.

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_Canonical: https://longevity-switzerland.com/en/research/clearing-out-aging-cells-made-stem-cell-repair-work-far-better-in-mice · Part of Longevity Cities · Updated 2026-06-08_