# How a Cellular Calcium Glitch Speeds Up Aging in Mice

*Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article
- **Journal**: Nature communications
- **Sample Size**: Mice and human cells (lab study)
- **Authors**: Xiang W, Hu Q, Sun P, Wu X, Jiang H, Qu M, Li L, Wang Y, Wang Z, Liu X, Ma J, Zhu D, Li H, Wang Y, Jiao Y, Huang B, Lu J, Cong X, Li W, Zhang Y
- **Published**: 2026-06-06
- **Topics**: calcium, aging, cellular senescence
- **DOI**: https://doi.org/10.1038/s41467-026-74021-z
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42251040/

## Summary

When cells lose control of their calcium balance, it sets off a chain reaction that triggers DNA damage and inflammation tied to aging. In mice, an old antidepressant called mianserin calmed this calcium chaos. It improved several signs of aging and lengthened their lives. This points to calcium control as a possible target for slowing aging.

## Practical Takeaway

This study suggests calcium balance inside cells may be a future target for aging research.

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_Canonical: https://longevity-switzerland.com/en/research/how-a-cellular-calcium-glitch-speeds-up-aging-in-mice · Part of Longevity Cities · Updated 2026-06-06_