# How Cutting Calories May Rejuvenate the Body's Aging Stem Cells

*Caloric restriction rejuvenates aged adult stem cells: From mechanisms to interventions.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article, Review
- **Journal**: Ageing research reviews
- **Sample Size**: N/A
- **Authors**: Chai Y, Liu X, Bi J, Zeng J, Yao M, Shi F, Xu S
- **Published**: 2026-06-11
- **Topics**: caloric restriction, stem cells, mTOR
- **DOI**: https://doi.org/10.1016/j.arr.2026.103204
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42276422/

## Summary

Our stem cells repair tissue, but they slow down as we age. This review looks at how eating less, known as caloric restriction, can refresh tired stem cells in blood, gut, brain, and muscle. Much of the effect runs through a nutrient-sensing pathway called mTOR, the same one that drugs like rapamycin target.

## Practical Takeaway

This review suggests caloric restriction may help refresh aging stem cells, mostly based on animal work.

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_Canonical: https://longevity-switzerland.com/en/research/how-cutting-calories-may-rejuvenate-the-body-s-aging-stem-cells · Part of Longevity Cities · Updated 2026-06-11_