# Selenium Levels and Fatty Liver: Is There a Sweet Spot for Survival?

*Nonlinear association between serum selenium and all-cause mortality in U.S. adults with NAFLD: a cohort study.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article
- **Journal**: Scandinavian journal of gastroenterology
- **Sample Size**: 1,787 U.S. adults with NAFLD
- **Authors**: Ma Y, Chai X, Wu W, Gu D, Yi P, Wang Z, Zhuang W
- **Published**: 2026-05-30
- **Topics**: selenium, fatty liver, mortality
- **DOI**: https://doi.org/10.1080/00365521.2026.2679098
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42217250/

## Summary

In nearly 1,800 American adults with fatty liver disease, those with higher blood selenium had a 64% lower risk of dying from any cause compared to the lowest group. But the benefit plateaued once selenium hit about 200 μg/L, so more wasn't better. Older adults and people with high blood pressure seemed to benefit most.

## Practical Takeaway

This study suggests moderate selenium levels may be linked to better survival in fatty liver patients.

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