# Strength Training May Reshape Brain Markers in Older Adults With Early Alzheimer's Signs

_Evidence Level: Preliminary · Age and ageing_

- **Evidence Level**: Preliminary
- **Why this grade**: Secondary analysis of a single-site randomized trial in 90 older adults over 24 weeks, with the clearest effect confined to a small amyloid-positive subgroup.
- **Facts**: Funding: MCIN/AEI/10.13039/501100011033 and FSE+; Spanish Ministry of Science…
- **Journal**: Age and ageing
- **Sample Size**: 90 cognitively healthy older adults, mean age 72, 58% female
- **Graded and published**: 2026-04-04
- **Last edited**: 2026-09-17
- **Topics**: Alzheimer's, exercise, brain health
- **Free full text**: https://pmc.ncbi.nlm.nih.gov/articles/PMC13071408/
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/41967036/
- **Registration**: ClinicalTrials.gov NCT05186090 (https://clinicaltrials.gov/study/NCT05186090)

## Summary

A 24-week strength training program altered Alzheimer's-related brain signatures in cognitively healthy older adults. The effect was strongest in participants who already had amyloid buildup in their brains. Those reductions in brain thickness markers were linked to better executive function, suggesting the changes were adaptive rather than harmful. This was a small trial of 90 people around age 72, so the results need replication.

## Practical Takeaway

This study suggests resistance training may support brain health in those with early amyloid buildup.

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_Canonical: https://longevity-germany.com/en/research/strength-training-may-reshape-brain-markers-in-older-adults-with-early-alzheimer-s-signs · Part of Longevity Cities · Updated 2026-09-17_