# Vitamin D and Vitamin E May Boost a Weakening Immune System in Older Adults

*Effects of micronutrient supplementation on immune function in older adults: a meta-analysis.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article, Systematic Review
- **Journal**: Frontiers in immunology
- **Sample Size**: N/A (review of 9 trials in older adults)
- **Authors**: Li D, Wang T, Xiao L, Li K
- **Published**: 2026-05-22
- **Topics**: vitamin D, vitamin E, immune health
- **DOI**: https://doi.org/10.3389/fimmu.2026.1732861
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42254024/

## Summary

As we age, our immune system gets sluggish and inflammation creeps up. Looking at nine trials, researchers found that vitamin and mineral supplements modestly improved immune function in older adults. Vitamin D lowered inflammation and raised immune cell activity, while vitamin E had the biggest effect on cell-based defenses. The overall boost was real but small.

## Practical Takeaway

This study suggests vitamin D and vitamin E may support immune function in older adults.

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