# What Centenarians' Immune Systems Reveal About Escaping Age-Related Disease

*The long-lived immune system of centenarians.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article, Review
- **Journal**: Nature reviews. Immunology
- **Sample Size**: N/A
- **Authors**: Plaza-Florido A, Carrera-Bastos P, Pérez-Prieto I, Fiuza-Luces C, Radom-Aizik S, Del Pozo Cruz B, Franceschi C, López-Soto A, López-Otín C, Lucia A
- **Published**: 2026-04-23
- **Topics**: centenarians, immune aging, inflammation
- **DOI**: https://doi.org/10.1038/s41577-026-01291-5
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42026253/

## Summary

People who live past 100 tend to have immune systems that look surprisingly young. This review found they have less chronic inflammation, better cellular cleanup (autophagy), and gut bacteria patterns linked to healthy aging. Those living past 110 often have immune profiles resembling much younger adults.

## Practical Takeaway

This research suggests that keeping inflammation low may be one pillar of reaching extreme old age.

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_Canonical: https://longevity-switzerland.com/en/research/what-centenarians-immune-systems-reveal-about-escaping-age-related-disease · Part of Longevity Cities · Updated 2026-04-23_