# Why Your Mitochondria May Be Driving Aging and Chronic Inflammation

*Mitochondrial drivers of stem cell aging and inflammaging.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article, Review
- **Journal**: npj aging
- **Sample Size**: N/A
- **Authors**: Bautista J, López-Cortés A
- **Published**: 2026-05-28
- **Topics**: mitochondria, NAD+, inflammaging
- **DOI**: https://doi.org/10.1038/s41514-026-00422-5
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42209503/

## Summary

Scientists are zeroing in on mitochondria (the energy factories in your cells) as a main driver of aging, not just a casualty of it. When they break down, they leak signals that trigger chronic, low-grade inflammation and exhaust stem cells. This review highlights NAD+ depletion as a key bottleneck and looks at fixes like NAD+ boosters and mitophagy enhancers.

## Practical Takeaway

This review suggests strategies that support mitochondrial health may matter for healthy aging.

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_Canonical: https://longevity-switzerland.com/en/research/why-your-mitochondria-may-be-driving-aging-and-chronic-inflammation · Part of Longevity Cities · Updated 2026-05-28_