Weak Grip Strength Linked to Higher Risk of Pneumonia and Sepsis

Based on: Handgrip strength and risk of common infections and sepsis: Two prospective cohorts with proteomic mediation analysis.

Strong Evidence·Journal Article·Archives of gerontology and geriatrics·Jun 2026

In over 400,000 UK adults, weaker handgrip strength was tied to higher rates of pneumonia, UTIs, skin infections, and sepsis. Each 5-kg drop in grip raised infection risk by about 5-10%. The link was strongest in underweight people, and inflammation-related proteins like GDF15 partly explained it.

Key Insight

This study suggests building grip and overall muscle strength may support immune resilience as you age.

Original Paper

Mak JKL, Krishnamoorthy S, Zhang X, Lin SY, Zheng HF, Tan KCB, Kung AWC, Cheung CL

Archives of gerontology and geriatrics··405,451 UK adults plus 4,474 Chinese adults

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.