Journal ArticleNature communications·Graded and published ·Last edited
A Tiny RNA Fragment May Be Key to How Fasting Extends Lifespan
Graded Preliminary — genetic screen and mechanistic experiments in C. elegans worms and mammalian cell cultures, with no testing in people.
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- National Research Foundation of Korea (NRF)
Scientists found that an enzyme called DIS3 chops transfer RNAs into small pieces that help slow aging. In worms, one fragment called 5'-tRH-Gln was needed for the lifespan boost from dietary restriction. The same system delayed cell aging in mammalian cells, pointing to a shared longevity mechanism across species.
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