Fat Tissue Controls Lifespan Through Insulin Signaling in Fruit Flies
In fruit flies, dialing down a gene called Dicer-1 in fat tissue extended lifespan. It worked even when flies were already on calorie restriction. The mechanism involves a chain reaction: lower Dicer-1 reduces a small RNA molecule in fat, which boosts a hormone that then tells the brain to release less insulin. Less insulin signaling is a well-known longevity pathway across species.
Original Paper
Related Studies
Eight Hyped Compounds Failed to Extend Lifespan in a Major Mouse Study
The NIA's Interventions Testing Program tested eight compounds across three lab sites in genetically diverse mice. None extended lifespan. That includes astaxanthin, alpha-ketoglutarate, pioglitazone,...
Fish That Age Fast Reveal Predictable 'Life Stages' in Aging
Scientists tracked African killifish behavior continuously from adolescence to death. Long-lived fish behaved differently from short-lived ones surprisingly early in life. Machine learning could actua...
Fish-Eaters and Vegetarians Show Slower Biological Aging Than Regular Meat-Eaters
Among over 400,000 UK adults, people who ate fish but little meat aged the slowest biologically. Vegetarians came in a close second. Regular meat-eaters aged fastest by two different biological age me...
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.