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Higher Vitamin C in the Blood Is Linked to Healthier Brain Structure

Based on: Plasma vitamin C levels are associated with brain structural networks on MRI: A large cohort study.

Moderate Evidence·Journal Article·PloS one·Jun 2026

In older adults, people with more vitamin C in their blood tended to have more gray matter and better connections in a key brain network. This held up even after accounting for age, education, and conditions like diabetes. It's a snapshot in time, so it can't prove vitamin C protects the brain.

Key Insight

This study links higher blood vitamin C to healthier brain structure, but it can't prove cause.

Original Paper

Nagaya H, Watanabe K, Shintaku T, Sasaki M, Kudo J, Kasai S, Ishimoto Y, Saito K, Matsuhashi S, Koshiishi T, Imura M, Ozawa A, Mori S, Watanabe D, Shukunobe S, Sasaki T, Tatsuo S, Kakehata S, Mikami T, Kokubu D, Ushida Y, Kakeda S

PloS one··2,044 older adults, median age 69

Conflict of Interest Disclosure: Two authors work for and hold stock in KAGOME, a health-promotion company that funded a department at the university.

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Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.