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Journal ArticleReviewNature reviews. Drug discovery·Sep 2026

The Drug Pipeline Aiming to Stop Age-Related Muscle Loss

Key Insight

This review suggests muscle-preserving drugs are still years away, so training and protein remain the main tools.


Losing muscle with age, called sarcopenia, raises the risk of falls, fractures, and early death. Right now there is no approved drug for it. This review walks through what's in development, including NAD+ boosters, urolithin A, myostatin blockers, and mTOR inhibitors like rapamycin. Researchers are also testing drugs alongside GLP-1 weight loss medications to stop people from losing muscle while they slim down.

Conflict of Interest Disclosure: One author cofounded a biotech company developing muscle drugs; two authors work for Nestlé and Regeneron.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.