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Cell biology

Loss of proteostasis

DEVerlust der Proteostase

Loss of proteostasis is one of the established hallmarks of aging and describes the age-related decline of the protein quality control network. Chaperones become less efficient, the proteasome and autophagy slow down, and misfolded or aggregation-prone proteins accumulate. The resulting proteotoxicity contributes to neurodegenerative disorders, cardiac amyloidosis, and cellular dysfunction across tissues, making proteostasis enhancers an active longevity research target.

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Sources

  1. Klaips CL, Jayaraj GG, Hartl FU. (2018). Pathways of cellular proteostasis in aging and disease. *Journal of Cell Biology*doi:10.1083/jcb.201709072
  2. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. (2023). Hallmarks of aging: An expanding universe. *Cell*doi:10.1016/j.cell.2022.11.001