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Journal ArticleiScience·Apr 2026

Frailty Doubles Death Risk in People With Heart and Metabolic Disease

Key Insight

This study suggests frailty checks could matter even for younger adults with heart or metabolic issues.


Looking at five large studies across the US, UK, and China, people with heart or metabolic conditions who were frail had up to 132% higher risk of dying from any cause. Even being slightly weak (pre-frail) raised the risk by 21% to 66%. The link was strongest in people under 65 and those with lower body weight.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.