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Journal ArticleCell stem cell·Jul 2026

How Chronic Stress Ages Your Blood Stem Cells Through the Gut

Key Insight

This early animal work hints that managing chronic stress may help protect blood-forming stem cells.


In mice, ongoing psychological stress made blood-forming stem cells act older and worn out. The stress worked through a brain-gut connection, cutting levels of a helpful gut bacteria and a compound called spermidine. Restoring those levels helped protect the stem cells. This links stress, gut health, and aging in a surprising chain.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.