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Cell biology

Advanced glycation end-products (AGEs)

DEAdvanced Glycation End-products (AGEs)

Advanced glycation end-products (AGEs) are stable, often crosslinked compounds. They form when sugars react with your proteins, lipids, or DNA over time. They build up in long-lived tissues like your skin, cartilage, and artery walls, where they impair elasticity and function. AGEs also activate a receptor called RAGE, which triggers inflammation and oxidative stress. Their build-up is linked to diabetes complications, atherosclerosis, kidney disease, and skin aging.

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Sources

  1. Bierhaus A, Humpert PM, Morcos M, et al. (2005). Understanding RAGE, the receptor for advanced glycation end products. Journal of Molecular Medicinedoi:10.1007/s00109-005-0688-7
  2. Brownlee M. (2001). Biochemistry and molecular cell biology of diabetic complications. Naturedoi:10.1038/414813a

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