Metformin's Anti-Aging Case: Strong Clues but Still No Proof

This review pulls together lab, population, and clinical trial evidence on metformin as a potential aging-slowing drug. At normal doses, metformin seems to flip several key aging switches: boosting cellular cleanup, calming inflammation, and improving energy production. Large population studies link metformin use to lower rates of age-related diseases, even in people without diabetes. However, the review honestly notes that metformin may actually worsen aging in older animals, so the picture is still mixed.