Scientists Find Universal Aging Signatures Across Mice, Monkeys, and Humans
Based on: Universal transcriptomic hallmarks of mammalian ageing and mortality.
Researchers pulled together over 11,000 gene activity samples from four mammal species to find what aging actually looks like at the molecular level. They found shared signatures across species, including two markers (CDKN1A and LGALS3) that also tracked with death risk and multiple diseases in UK Biobank data. Caloric restriction mainly slowed aging in mitochondrial pathways, while chronic diseases sped up inflammation-related aging.
Key Insight
This research is mechanistic, but it supports the idea that inflammation and mitochondrial health are key aging levers.
Original Paper
Tyshkovskiy A, Kholdina D, Davitadze M, Molière A, Moldakozhayev A, Tongu Y, Kasahara T, Glubokov D, Eames A, Kats LM, Vladimirova A, Ying K, Liu H, Zhang B, Khasanova U, Moqri M, Van Raamsdonk JM, Harrison DE, Strong R, Abe T, Dmitriev SE, Gladyshev VN
Conflict of Interest Disclosure: Two authors filed a US patent related to this work.
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Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.