Senolytics Plus TB Drugs Boost Survival in Infected Mice
Graded Preliminary — mouse study in young, aged and susceptible strains testing senolytics with TB therapy, yet the benefit is limited to animals and has not been tested in people.
- Design
- —
- Participants
- —
- Duration
- —
- Funding
- NHLBI NIH HHS; NIAID NIH HHS; Division of Intramural Research, National…
This study suggests senolytic drugs may warrant testing as add-on therapy for tuberculosis in humans.
Tuberculosis triggers some lung cells to become senescent (zombie-like cells that won't die but cause damage). Researchers gave infected mice a senolytic cocktail of dasatinib, quercetin, and fisetin alongside standard TB treatment. The combo improved survival and reduced lung damage, especially in older mice.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.