Oxidative stress

Oxidative stress is an imbalance between reactive oxygen species production and the body's antioxidant defences, leading to oxidative damage of biomolecules. It impairs mitochondrial function, accelerates telomere attrition, and drives chronic low-grade inflammation. Implicated in many hallmarks of ageing, oxidative stress is associated with cardiovascular disease, neurodegeneration, diabetes, and cancer, and is modulated by diet, exercise, sleep, and environmental exposures.