Metformin Added Nothing to Diet and Exercise for Older Adults' Strength
Graded Strong — randomised placebo-controlled trial in 114 older adults with obesity over 6 months, analysed by intention-to-treat, though 89% of participants were men.
- Design
- —
- Participants
- 114
- Duration
- —
- Funding
- None declared; funded by the US Department of Veterans Affairs.
This study suggests structured exercise and diet drive physical function gains, not metformin.
Metformin has a big fan club in longevity circles, but this trial puts a dent in the hype. Older adults with obesity, aged 65 to 85, did six months of serious diet and exercise coaching. Adding metformin on top gave zero extra improvement in physical function compared to a placebo. The lifestyle program itself was what moved the needle.
Conflict of Interest Disclosure: None declared; funded by the US Department of Veterans Affairs.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
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