Centenarians Show a Distinct Metabolic Profile Tied to Bile Acids and NAD+
People who live past 100 have a unique metabolic fingerprint. In a study of 213 participants from the New England Centenarian Study, extremely long-lived individuals had higher levels of certain bile acids and lower levels of bilirubin compared to younger controls. Higher bile acid and steroid levels were linked to lower mortality risk. The researchers also built a "metabolomic clock" that estimates biological age, and deviations from it predicted death risk.
Kernaussage
This study suggests bile acid metabolism and NAD+ pathways may be key targets in longevity research.
Originalstudie
Verwandte Studien
Tracking Your 'Biological Age' Over Time May Predict Death Risk Better Than a Single Snapshot
In over 90,000 Dutch adults followed for nearly 14 years, people whose biological age ran ahead of their calendar age had a higher risk of dying. More importantly, among 25,000 people measured twice, those whose biological age sped up over time faced even greater risk. People stuck in a pattern of accelerated aging had a 39% higher mortality risk compared to those aging at a normal pace. The results suggest that checking biological age once might not be enough.
We May Not Be Aging Slower. We're Just Starting Later.
A big question in longevity research is whether rising life expectancy means we're actually aging more slowly. This analysis of mortality data from 12 countries suggests the answer is no. After accounting for historical shocks like wars and pandemics, the rate at which aging accelerates after 80 hasn't changed. The gains in lifespan appear to come from pushing back when serious aging begins, not from slowing the process itself.
Metformin's Anti-Aging Case: Strong Clues but Still No Proof
This review pulls together lab, population, and clinical trial evidence on metformin as a potential aging-slowing drug. At normal doses, metformin seems to flip several key aging switches: boosting cellular cleanup, calming inflammation, and improving energy production. Large population studies link metformin use to lower rates of age-related diseases, even in people without diabetes. However, the review honestly notes that metformin may actually worsen aging in older animals, so the picture is still mixed.
Haftungsausschluss: Forschungszusammenfassungen dienen nur zu Informationszwecken und stellen keine medizinische Beratung dar. Konsultiere immer einen qualifizierten Arzt, bevor du Änderungen an deiner Gesundheitsroutine vornimmst.