What is the Longevity Research Library?

The Longevity Switzerland Research Library curates recent peer-reviewed studies on longevity, nutrition, exercise, sleep, and supplements. Each study is rated by evidence strength: Strong, Moderate, or Preliminary.

How are evidence levels determined?

Evidence levels are based on study type (meta-analysis, RCT, cohort study), sample size, journal impact factor, and reproducibility of findings.

Research Digest

Research Library

Peer-reviewed papers from top journals, summarized and graded by evidence strength. Updated Mon, Wed & Fri.

Evidence

6/115

Topic

Jun 7–13, 2026

1 study

senolytics

Clearing Out Aging Cells Made Stem Cell Repair Work Far Better in Mice

Old, worn-out cells (called senescent cells) seem to block the body's natural repair work. In mice with liver damage and forced aging, combining a treatment that clears these cells with stem cell therapy worked far better than either alone. The combo reversed signs of aging and restored repair signals. This is early animal research, not tested in people.

Journal of translational medicine·Preliminary·Jun 8, 2026

May 24–30, 2026

1 study

mitochondria

Why Your Mitochondria May Be Driving Aging and Chronic Inflammation

Scientists are zeroing in on mitochondria (the energy factories in your cells) as a main driver of aging, not just a casualty of it. When they break down, they leak signals that trigger chronic, low-grade inflammation and exhaust stem cells. This review highlights NAD+ depletion as a key bottleneck and looks at fixes like NAD+ boosters and mitophagy enhancers.

npj aging·Moderate·May 28, 2026

Apr 12–18, 2026

1 study

exercise

How Lactate From Exercise May Rewrite Your Genes to Slow Aging

When you work out hard, your muscles pump out lactate, the same stuff people used to blame for soreness. Researchers now think lactate acts as a messenger that tags proteins through a process called lactylation, linking your workout to long-term changes in how genes behave. This may explain how exercise protects mitochondria, calms inflammation, and keeps stem cells working across the brain, heart, and muscles. It's still early, and much of the evidence comes from animal and cell studies.

Ageing research reviews·Preliminary·Apr 15, 2026

Mar 22–28, 2026

2 studies

epigenetics

Why Your Skin Never Forgets Inflammation, Even Years Later

In mice, skin stem cells can hold lifelong "memories" of past inflammation like psoriasis flares. These memories are stored as epigenetic changes. Specific DNA sequences rich in CpG patterns keep the memory accessible through cell divisions. This means once skin has been inflamed, its stem cells stay primed to react faster and stronger to future triggers.

Science (New York, N.Y.)·Preliminary·Mar 26, 2026

aging-biology

Lab-on-a-Chip Mimics Decades of Human Aging in Just 4 Days

Researchers built a tiny organ-on-a-chip using human stem cells to model how fat tissue and the liver age together. By exposing it to blood serum from older people, the chip reproduced decades' worth of aging hallmarks in just 4 days. These included DNA damage and gene expression shifts seen in actual aged tissues. The system also revealed sex-based differences in aging and how fat aging spills over to affect the liver.

Nature biomedical engineering·Preliminary·Mar 25, 2026

Mar 15–21, 2026

1 study

cardiovascular health

How Mutant Blood Stem Cells May Quietly Fuel Heart Disease as You Age

As people age, blood stem cells accumulate mutations that cause certain cell lines to expand. This process, called clonal hematopoiesis, is now strongly linked to increased cardiovascular risk in older adults. The mutant blood cells appear to ramp up inflammation, accelerating atherosclerosis and heart failure. This review covers how these rogue clones interact with age-related inflammation and what future therapies might look like.

Acta pharmacologica Sinica·Moderate·Mar 16, 2026

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.

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